...The Four Pathogenic Factors Involved in AcneAn increase in the levels of androgens before and during adolescence leads to the production of greater amounts of sebum.The bacterium Propionibacterium acnes, which is resident on the skin of even healthy individuals, thrives on sebum. Increased sebum production in acne patients results in a proliferation of this micro-organism.Something goes awry in the infundibulum of the follicle in acne patients that causes cells from the follicle wall to clump together. This abnormal keratinization results in the clogged pores, or microcomedones, that can later proceed to other acne lesions.The presence of P acnes triggers the release of chemotactic factors that cause inflammation, as manifested by papules, pustules, and nodules....»
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«...Development of acne vulgaris in later years is uncommon, although this is the age group for Rosacea which may have similar appearances. True acne vulgaris in adults may be a feature of an underlying condition such as pregnancy and disorders such as polycystic ovary syndrome or the rare Cushing's syndrome. Menopause-associated acne occurs as production of the natural anti-acne ovarian hormone estradiol fails at menopause. The lack of estradiol also causes thinning hair, hot flashes, thin skin, wrinkles, vaginal dryness, and predisposes to osteopenia and osteoporosis as well as triggering acne (known as acne climacterica in this situation)....»
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